Nitric Oxide and Health

What is Nitric Oxide?

Nitric oxide is a chemical messenger which cannot be stored and can rapidly diffuse across cell membranes to act at remote sites in the body; it is a very important signaling molecule that plays a crucial role in various physiological processes. This remarkable gas is highly unstable, so it is converted to nitrites and nitrates within approximately 10 seconds of being produced, which further highlights its transient yet significant role in the body. Nitric oxide is present in most living organisms and is synthesized by numerous cell types, including endothelial cells, nerve cells, and white blood cells. It influences a vast array of biological functions, such as regulating blood flow, modulating immune responses, and facilitating communication between neurons. Its major function is the protection of all the blood vessels in the body, promoting vascular health and preventing conditions like hypertension. However, factors such as age, lifestyle, and dietary choices can lead to a decrease in the production of nitric oxide, which can negatively impact overall health and increase the risk of cardiovascular diseases. Maintaining optimal levels of nitric oxide is essential for overall well-being, so it important to be mindful of the factors that influence its production in the body.

Important Health Benefits

1. Heart Health

Nitric oxide plays a crucial role in protecting the heart and ensuring its optimal function. When blood vessels, which are responsible for carrying oxygen and vital nutrients to the heart as well as the rest of the body, become thick and stiff due to various factors such as poor diet, lack of exercise, and aging, the endothelium—the thin layer of cells lining the blood vessels—experiences a reduced capacity to produce nitric oxide. This decline in nitric oxide levels can significantly increase the risk of severe cardiovascular events, acting as a precursor to a heart attack. In such situations, medical treatment often involves the administration of nitroglycerin, a medication that facilitates a substantial increase in nitric oxide production. This surge in nitric oxide promotes the dilation of blood vessels, thereby enhancing blood flow to the middle muscular layer of the heart wall, which is essential for maintaining heart health and function. Furthermore, maintaining high levels of nitric oxide is vital not only for promoting adequate blood circulation but also for preventing the hardening of the arteries, the formation of plaque, and the development of potentially dangerous blood clots. As such, understanding and supporting the mechanisms that enhance nitric oxide production can lead to more effective strategies in promoting cardiovascular health and preventing heart-related diseases.

2. Regulates Blood Pressure.

High blood pressure may also be caused by low levels of nitric oxide, which plays a crucial role in vascular health. Nitric oxide, a gas produced within the endothelium, quickly spreads to the underlying smooth muscle cells of the arteries, where it activates signaling pathways that effectively turn off contractions. This biological process leads to dilation of the arteries, thereby lowering blood pressure and facilitating smoother blood flow throughout the circulatory system. Furthermore, the maintenance of adequate nitric oxide levels is vital for overall cardiovascular health, as it helps to prevent the development of hypertension. If the endothelial cells become damaged due to factors such as oxidative stress, inflammation, or unhealthy lifestyle choices, then the production of nitric oxide is significantly reduced. Consequently, this deficiency can result in impaired vascular function and an increase in blood pressure, posing risks for more serious cardiovascular diseases, such as heart attacks and strokes. Thus, ensuring the health of the endothelium is essential for maintaining optimal nitric oxide levels and preventing elevated blood pressure.

3. Stimulates the Brain

Studies have found that nitric oxide plays a crucial role as a neurotransmitter in the brain and is significantly involved in the complex processes of learning and memory. This fascinating molecule helps in modulating synaptic plasticity, which is essential for the encoding of new information and experiences. Due to the fact that it relaxes blood vessels, it allows an increased oxygen-rich blood supply to the brain, which is vital for maintaining optimal cognitive function and supporting various neural pathways. Moreover, nitric oxide not only enhances blood flow but also activates the computational ability of the brain, facilitating quicker processing of information and efficient decision-making. Given its importance in neural communication, it may play a pivotal role in the treatment of age-related degenerative diseases like Alzheimer’s, by potentially slowing down the progression of neurodegeneration and improving overall brain health in the elderly population. Further research into its mechanisms could unveil new therapeutic strategies aimed at promoting cerebral health and cognitive longevity.

4. Protects Against Cancer

The Journal of Cancer Prevention examined “The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention” and found that Nitric oxide significantly contributes to programmed cancer cell death (apoptosis), a critical process that eliminates damaged or potentially harmful cells in the body. This discovery underscores the importance of nitric oxide not just in the effective management of cancer but also in enhancing our understanding of molecular mechanisms that drive tumor growth and development. Additionally, The Nobel Prize in Physiology or Medicine 1998 highlighted in a press release that “White blood cells use nitric oxide not only to kill infectious agents such as bacteria, fungi, and parasites, but also to defend the host against tumours.” This dual function reinforces the integral role nitric oxide plays in maintaining the delicate balance of immune response, illustrating its potential as a therapeutic target in oncology. As researchers continue to investigate this compound, new strategies for cancer prevention and treatment may emerge, paving the way for innovative approaches in the fight against cancer.

5. Alleviates Impotence

Low levels of Nitric oxide can significantly influence erectile dysfunction, leading to challenges in sexual performance and overall satisfaction. Many of the drugs developed to combat erectile dysfunction leverage the crucial understanding that Nitric Oxide acts as a potent vasodilator, facilitating the initiation of an erection by relaxing and dilating the blood vessels in the penis. This physiological process is not only vital for males, but it is also essential in the arousal of females, as Nitric Oxide contributes to increased blood flow and heightened sensitivity in the genital area. Furthermore, maintaining healthy levels of Nitric Oxide is important for both genders, as it plays a role in overall cardiovascular health and can improve sexual function by enhancing pleasure and intimacy in relationships. Understanding the multifaceted roles of Nitric Oxide in sexual health can pave the way for more effective treatments and better sexual experiences.

6. Kills Bacteria

 When NO is produced in white blood cells (such as macrophages), huge quantities are achieved and become toxic to invading bacteria and parasites.

Nobel Prize in Physiology or Medicine 1998

What Causes a Reduction in Nitric Oxide

• Diabetes
• High intake of High Fructose Corn Syrup or sugar
• Inflammation
• Fatty foods
• Diet low in nitrates; green leafy vegetables
• Overuse of antacids: reduces stomach acid that helps change nitrites to nitric acid.
• Overuse of mouth washes; reduce bacteria the helps form nitrites from nitrates
• Age; by age fifty a female may be producing nitric oxide at a 35% capacity

Some of the above causes are interrelated. Diabetes is a result of over consumption of high fructose corn syrup, fats and inflammation.

Symptoms of Low Levels Of Nitric Oxide

• Poor memory and concentration
• Lethargy
• Heart Disease
• Asthma
• Hypertension
• Decreased Libido

How to Increase Nitric Oxide Levels

Nitric oxide is produced from foods rich in nitrates, which are essential for various bodily functions, particularly in promoting vascular health. When these nitrate-rich foods are chewed, they mix with salivary bacteria to produce nitrites, an important compound for the subsequent formation of nitric oxide. Dr. Esselstyn suggests using balsamic vinegar on our vegetable salads to increase the production of nitrites, enhancing the overall flavor and nutritional value of our meals. In the stomach, nitrites mix with stomach acids to form nitric oxide, which is quickly diffused across the cells, contributing to improved blood flow and oxygen delivery. This process is crucial for athletic performance and overall well-being. Please note that foods processed with nitrites, like deli meats, are actually health-destroying and may be cancer-causing due to the presence of harmful preservatives. Thus, it is vital to focus on natural sources of nitric oxide, as it cannot be obtained from a pill; it has to be produced by the body from the natural foods that are consumed. Vegetables are the best sources, as dark leafy greens such as spinach and arugula are particularly high in nitrates, but some fruits, especially pomegranates, are also relatively good sources, offering additional antioxidants that support cardiovascular health. Head over to the recipe page to find delicious and nutritious recipes that can boost your nitric oxide levels, helping you embrace a healthier lifestyle while enjoying a variety of flavors.

Caution

High levels of nitric oxide can be harmful when a person is in shock from bacterial infections because white blood cells release large amounts that dilate the vessels, thus lowering blood pressure to dangerous levels. This severe drop in blood pressure can lead to inadequate blood flow to vital organs, resulting in complications and potentially life-threatening situations. Consequently, the body struggles to deliver sufficient oxygen and nutrients to tissues, which can hinder recovery. Taking nitroglycerin, a medication that further vasodilates blood vessels, can exacerbate this condition, leading to hypotension, lethargy, excessive sweating, and dizziness. These side effects can significantly affect a patient’s overall well-being and complicate the management of their medical condition, necessitating careful monitoring and consideration by healthcare providers.

My Experience

I suffered two heart attacks and, after the second one, decided to go against conventional medical wisdom. During the first heart attack, I was given nitroglycerin and my blood pressure went so low that the nurses started to panic; it was a terrifying experience that left a lasting impression on me. I was given a dose of nitroglycerin to take in the event of another heart attack, but I never ended up taking it, as I wanted to explore other avenues for my health. After the second heart attack, I decided to go completely whole food, plant-based, with the invaluable help of a naturopathic doctor who guided me throughout my journey. I eat lots of fruits and vegetables, incorporating a rich variety of colors and nutrients into my meals daily, and make a concerted effort to drink nitric oxide boosting beverages every day, which have become a vital part of my routine. The results have been nothing short of remarkable. My blood pressure, which could spike as high as 220/102 during my earlier health struggles, is now most times at a stable 116/78, sometimes slightly above or below, but always within a much healthier range. I wake up feeling well-rested and have a surge of energy throughout the day. I can now walk 6 miles without feeling any stress, and I make it a point to exercise for an hour each night before bed, which has become a cherished part of my daily life. My eye doctor, who was previously concerned that I might be developing macular degeneration due to various symptoms, was pleasantly surprised to see that all those symptoms had completely disappeared during my last visit! At age 60, I no longer experience “headaches,” and I’m thrilled that my libido has increased exponentially, adding a new vibrancy to my life that I had thought was lost. I am so glad I discovered Nitric Oxide and the transformative power of a plant-based lifestyle, which has truly revitalized my body and spirit.

An Invitation

I have experienced the benefits of increased nitric oxide levels and I would like for you to do the same. This is a natural process that our Creator has put in place. There is no need to buy chemicals, just eat your veggies and fruits daily and boost the production of nitric oxide using the recipes given. Here’s to your health for 2020! Please come back and comment after you have tried my recipes and tell us how it has helped you. What do you think?